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Research

The coordination of both basic and clinical research is an essential component of the Center for Children. It fosters innovative and state-of-the-art care, as well as contributing to the finding of basic knowledge.

The basic research will be focused on the molecular pathogenesis of connective tissue, neuromuscular disorders and bone dysplasias. This will be coordinated with genetic therapeutics including antisense therapy, modalities of therapy and potential new small molecule therapies.

Clinical research will also include sophisticated databasing in determining outcome measures of disease and treatment.

 

Selected Publications

AVASCULAR NECROSIS (AVN)

Gomez JA, Matsumoto H, Roye DP, Vitale MG, Hyman JE, van Bosse HJP, Marangoz S, Sala DA, Stein MI, Feldman DS. Articulated hip distraction: a treatment option for femoral head avascular necrosis in adolescence.Journal of Pediatric Orthopaedics 2009;29:163-169.

ARTHROGRYPOSIS 

Sala DA, Rosenthal DL, Grant AD. Early treatment of an infant with severe arthrogryposis. Physical & Occupational Therapy in Pediatrics 1996;16:73-89.

BACK PAIN

Feldman DS, Straight JJ, Badra MI, Mohaideen A, Madan SS.Evaluation of an algorithmic approach to pediatric back pain. Journal of Pediatric Orthopaedics 2006;26:353-357. 

Sala DA, Chu MLY, Moran E, Bencardino J, Vine DT. Tethered cord in a patient with multiple vertebral segmentation defects: a case report. Bulletin Hospital for Joint Diseases 2001-2002;60:96-99.  

BLOUNT’S DISEASE

Feldman DS, Madan SS, Ruchelsman DE, Sala DA, Lehman WB. Accuracy of correction of tibia vara: acute versus gradual correction. Journal of Pediatric Orthopaedics 2006;26:794-798.

Feldman DS, Madan SS, Koval KJ, van Bosse HJP, Bazzi J, Lehman WB.  Correction of tibia vara with six-axis analysis and the Taylor Spatial Frame. Journal of Pediatric Orthopaedics 2003:23:387-391.

CLUBFOOT 

Chu A, Labar AS, Sala DA, van Bosse HJP, Lehman WB. Progression of idiopathic clubfoot correction using the Ponseti method. Presented at POSNA in Boston, April 29-May 2, 2009.

Abdelgawad AA, Lehman WB, van Bosse HJP, Scher DM, Sala DA. Treatment of idiopathic clubfoot using the Ponseti method: minimum 2-year follow-up. Journal of Pediatric Orthopaedics B 2007;16:98-105.

Thacker MM, Scher DM, Sala DA, van Bosse HJP, Feldman DS, Lehman WB. Use of foot abduction orthosis following Ponseti Casts: Is It Essential? Journal of Pediatric Orthopaedics 2005;25:225-228.

Scher DM, Feldman DS, van Bosse HJP, Sala DA, Lehman WB.  Predicting the need for tenotomy in the Ponseti method for correction of clubfeet. Journal of Pediatric Orthopaedics 2004;24(4):349-352.

Lehman WB, Mohaideen A, Madan S, Scher DM, van Bosse HJP, Iannacone M, Bazzi JS, Feldman DS.  A method for the early evaluation of the Ponseti (Iowa) technique for the treatment of idiopathic clubfoot. Journal of Pediatric Orthopaedics B 2003;12:133-140.

Tareco J, Sala DA, Scher DM, Lehman WB, Feldman DS. Percutaneous fixation in clubfoot surgery: a radiographic and gait study. Journal of Pediatric Orthopaedics B 2002;11:139-142.

FAMILIAL DYSAUTONOMIA

Feldman DS, Ruchelsman DE, Spencer DB, Straight JJ, Schweitzer ME, Axelrod FB. Peripheral arthropathy in hereditary sensory and autonomic neuropathy types III and IV. Journal of Pediatric Orthopaedics 2009;29:91-97.

Henderson ER, Sala DA, Schweitzer ME, Feldman DS. Limited cervical range of motion in patients with familial dysautonomia. Presented at POSNA in Boston, April 29-May 2, 2009.

FOOT

Feldman DS, Madou MRZ, Chu A, Sala DA, van Bosse HJP, Chorney GS. Results of resection for talocalcaneal and calcaneonavicular tarsal coalitions. Presented at POSNA in Albuquerque, NM, April 30-May 3, 2008.

Shybut TB, Rose DJ, Strongwater AM. Second metatarsal physeal arrest in an adolescent Flamenco dancer: a case report. Foot & Ankle International 2008;29:859-862. 

Sala DA, Shulman LH, Grant AD, Chu MLY. Idiopathic toe-walking: a review. Developmental Medicine and Child Neurology 1999;41:846-848.

Shulman LH, Sala DA, Chu MLY, McCaul PR, Sandler BJ. Developmental implications of idiopathic toe walking. Journal of Pediatrics 1997;130:541-546.

FRACTURES

Reinhardt KR, Feldman DS, Green DW, Sala DA, Widmann RF, Scher DM. Comparison of intramedullary nailing to plating for both-bone forearm fractures in older children. Journal of Pediatric Orthopaedics 2008;28:403-409.

Henderson ER, Egol KA, van Bosse HJP, Schweitzer ME, Pettrone SK, Feldman DS. Calculation of rotational deformity in pediatric supracondylar humerus fractures. Skeletal Radiology 2007;36:229-235.

HIP

Takemoto RC, Strongwater AM. Pelvic osteomyelitis mimicking septic hip arthritis: a case report. Journal of Pediatric Orthopaedics B 2009:18:248-251. 

Anand A, Chorney GS. Patient survey of weight-bearing and physical activity after in situ pinning for slipped capital femoral epiphysis. American Journal of Orthopedics 2007;36:E68-E70. 

Thacker MM, Feldman DS, Madan SS, Straight JJ, Scher DM. Hinged distraction arthroplasty of the adolescent arthritic hip. Journal of Pediatric Orthopaedics 2005;25:178-182. 

HIP DYSPLASIA  [PERIACETABULAR OSTEOTOMY (GANZ)]

Landa J, Benke M, Feldman DS. The limbus and the neolimbus in developmental dysplasia of the hip. Clinical Orthopaedics and Related Research 2008;466:776-781.

Badra MI, Anand A, Straight JJ, Sala DA, Ruchelsman DE, Feldman DS. Functional outcome in adult patients following Bernese periacetabular osteotomy. Orthopedics 2008;31:69.

Ruchelsman DE, Feldman DS. Minimizing osteotomy related complications for abductor sparing periacetabular osteotomy using C-arm image intensification. Orthopedics 2007;30:467.

LIMB LENGTH INEQUALITY AND LIMB DEFORMITIES 

Lehman WB, Abdelgawad AA, Sala DA. Congenital tibial dysplasia (congenital pseudoarthrosis of the tibia): an atypical variation. (Point of view) Journal of Pediatric Orthopaedics B 2009;18:211-213.

Feldman DS, Duncan D, Ustunkan F, Kummer FJ. Anatomic and radiographic study to ensure accurate positioning of tension band plates (8 plates). Presented at POSNA in Boston, April 29-May 2, 2009.

Marangoz S, Feldman DS, Sala DA, Hyman JE, Vitale MG. Femoral deformity correction in children and young adults using Taylor spatial frame. Clinical Orthopaedics and Related Research 2008;466:3018-3024.

Henderson ER, Feldman DS, Lusk C, van Bosse HJP, Sala DA, Kummer FJ. Conformational instability of the Taylor spatial frame: a case report and biomechanical study. Journal of Pediatric Orthopaedics 2008;28:471-477.

Feldman DS, Henderson ER, Levine HB, Schrank PL, Koval KJ, Patel RJ, Spencer DB, Sala DA, Egol KA. Interobserver and intraobserver reliability in lower-limb deformity correction measurements. Journal of Pediatric Orthopaedics 2007;27:204-208.

Feldman DS, Madan SS, Ruchelsman DE, Sala DA, Lehman WB. Accuracy of correction of tibia vara: acute versus gradual correction. Journal of Pediatric Orthopaedics 2006;26:794-798.

Anand A, Feldman DS, Patel RJ, Lehman WB, van Bosse HJP, Badra MI, Sala DA. Interobserver and intraobserver reliability of radiographic evidence of bone healing at osteotomy sites. Journal of Pediatric Orthopaedics B 2006;15:271-272.

Ruchelsman DE, Madan SS, Feldman DS. Genu valgum secondary to focal fibrocartilaginous dysplasia of the distal femur. Journal of Pediatric Orthopaedics 2004;24:408-413.

Feldman DS, Shin SS, Madan S, Koval KJ. Correction of tibial malunion and nonunion with six axis analysis deformity correction using the Taylor spatial frame.  Journal of Orthopaedic Trauma 2003;17(8):549-554.

Feldman DS, Madan SS, Koval KJ, van Bosse HJP, Bazzi J, Lehman WB. Correction of tibia vara with six-axis analysis and the Taylor Spatial Frame.  Journal of Pediatric Orthopaedics 2003:23:387-391.

LOWER EXTREMITY CONDITIONS

Chu, A, Madou MRZ, Sala DA, Chorney GS, Feldman DS. Outcomes analysis after routine removal of implants in healthy pediatric patients. Journal of Pediatric Orthopaedics B 2009;18:381-387. 

Alwattar BJ, Strongwater A, Sala DA. Streptococcal toxic shock syndrome presenting as septic knee arthritis in a 5-year-old child. Journal of Pediatric Orthopaedics 2008;28:124-127.

Abdelgawad AA, Rybak LD, Sheth M, Rabinowitz SS, Jayaram N, Sala DA, van Bosse HJP. Treatment of acute salmonella epiphyseal osteomyelitis using computed tomography-guided drainage in a child without sickle cell disease. Journal of Pediatric Orthopaedics B 2007;16:415-418.

Kummer FJ, Grant AD. Possible errors in pin insertion positions using the C-arm. Bulletin Hospital for Joint Diseases 2004;62:67-68. 

SPASTICITY/CEREBRAL PALSY 

Chu ML, Sala DA. The use of tiagabine in pediatric spasticity management. Developmental Medicine and Child Neurology 2006;48:456-459.

Blate M, Bodden A, Leonard KF, Chu ML, Feldman DS, Goldstein H, Rabito M, Sala DA, Weiner HL.  Weight change associated with intrathecal baclofen.  Presented at American Academy for Cerebral Palsy and Developmental Medicine, New Orleans, Louisiana, September, 2002.

Chu ML, Sala DA, Weiner HL. Intrathecal baclofen in X-linked adrenoleukodystrophy. Pediatric Neurology 2001;24:156-158.

Kopell BH, Sala DA, Doyle WK, Feldman DS, Wisoff JH, Weiner HL. Subfascial implantation of intrathecal baclofen pumps in children: a technical note. Neurosurgery 2001;49:753-757.

Sala DA, Grant AD, Kummer KJ. Equinus deformity in cerebral palsy: recurrence after tendo Achillis lengthening. Developmental Medicine and Child Neurology 1997;39:45-48.

Grant AD, Sala DA, Kummer FJ, Kiriakatis A. A simple technique for assessing heel contact in orthoses. Journal of Pediatric Orthopaedics 1996;16:385-387.

Sala DA, Grant AD. Prognosis for ambulation in cerebral palsy. Developmental  Medicine and Child Neurology1995;37:1020-1026.